药品名称：心韻定（决奈达隆）multaq
药品别名：决奈达隆
研发公司：法国赛诺菲-安万特制药集团
适 用 症：适用于阵发性或持续性心房颤动AF或心房扑动AFL患者，减低住院风险。
型号规格：400mg 60片装
功能与主治
心韻定（决奈达隆）multaq是抗心律失常药w，适用于阵发性或持续性心房颤动AF或心房扑动AFL患者，减低住院风险，近期AF/AFL发作和伴心血管风险因子患者，即年龄>70、高血压、糖尿病、既往心血管意外、左心房直径>=50mm或左心室射血分数LVEF<40%，以及窦性心律或心律可复律的患者。
型号与规格
400mg 60片装。
用法与用量
每天2次，早和晚餐各1片400mg。
临床研究
电生理效应：
决奈达隆表现出所有四种Vaughn-Williams抗心律失常类别的性质，尽管不清楚其中哪个对决奈达隆产生的临床效应重要。健康受试者重复口服剂量达1600mg每天次或800mg每天两次，共14天，和1600mg每天2次共10天后研究决奈达隆对12-导联ECG参数（心率、PR和QTC）的影响。决奈达隆400mg每天2次组，对心率无影响；在800mg每天2次注意到中度心率降d效应（约4bpm）。对PR-间隔有明确的剂量依赖效应，400mg每天2次增加+5ms和1600mg每天2次增+50ms，对QTC-间隔有中度剂量相关效应，400mg每天2次延c+10ms而1600mg每天2次达+25ms。
DAFNE研究
DAFNE是在复发性AF患者中的一项剂量-反应研究，比较评价决奈达隆与安慰剂维持窦性心律的效应。在本研究中决奈达隆的剂量为400，600和800mg每天2次。这个小研究中超过400mg剂量效应不是更有效而耐受性较差。
不良反应及禁忌
在说明书中任-何处描述担忧下列安quan性：
1、新心衰或心衰恶化；
2、钾消耗药的低钾血症和低镁血症；
3、QT延c；
z常见的不良反应有腹泻、恶心、、呕吐和虚弱。
禁忌
1、心衰类别IV或z近失代偿症状性心衰；
2、II-或III-度房室AV阻断或病态窦房结综合症；
3、心动过缓<50bpm；
4、同时用强CYP3A抑制剂；
5、同时用延cQT间隔及可y发扭转型室性心动过速的药w和草药；
6、QTC Bazett间隔>=500ms；
7、严重肝损伤；
8、妊娠；
9、哺乳母亲；
孕妇用药
禁用。
儿童用药
禁用。
贮藏
常温下避光贮藏。
生产厂家
法国赛诺菲-安万特制药集团
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